Is that Prozac in your pocket or do you just THINK you’re happy to see me?

5 03 2008

image ‘Has the Prozac bubble finally burst?’ asks this week’s New Scientist mag.

The article reports findings that antidepressants seem to offer no more than a placebo effect, except in the most severely depressed people.

And those severely depressed people respond less to placebos, not more to the drugs.

Reports of subjects’ happiness have been greatly exaggerated

The study involved UK and US researchers and looked at all clinical trials submitted to the FDA for the licensing of the 4 SSRIs with complete datasets:

  • Fluoxetine (Prozac)
  • Venlafaxine
  • Nefazodone
  • Paroxetine (Seroxat or Paxil)

The conclusion?

‘Compared with placebo, the new-generation antidepressants do not produce clinically significant improvements in depression in patients who initially have moderate or even very severe depression.’

SSRI specialist David Healy of Cardiff University said in an earlier New Scientist article that this latest research confirms suspicions that the effectiveness of these drugs has been exaggerated.

‘Most importantly this new study shows that the people who did respond to the drugs would have responded to placebo, anyway.’

The file drawer problem

The change in mood toward these drugs also reflects the file drawer problem - the results not found in studies that don’t get published.

When Erick Turner of Oregon Health and Science University in Portland and his colleagues hunted through the literature they uncovered 23 unpublished studies, of which 22 found negative or questionable effects of antidepressants.

Because such studies don’t find clinically significant results they get relegated to the file drawer and fail to inform the broader picture of effectiveness.

Placebo placabo

There seems little dispute that antidepressants offer a placebo benefit. And to paraphrase The Bard, doesn’t a placebo by any other pharmaceutical name make you feel just as sweet?

David Nutt of Bristol Uni says yes - even a placebo benefit shouldn’t be discounted.

I guess that’s true.
And maybe the pharmaceutical companies could be paid with Monopoly money.

Don’t try this at home

I repeat New Scientist’s warning - if you’re on anti-depressants be sure to consult your doc before taking yourself off them.

Related articles:

 

Image: xianstudio




Happiness Life Strategy: How to be happy while waiting for the bus

3 03 2008

image ‘How long till the bus gets here?’

‘Should I walk instead?’

‘Maybe it’s just around the corner and then I’ll miss it.’

‘But if it’s not around the corner then how long till it gets here?’

If such Shakespearean dilemmas plaque your daily commute, you’ll be relieved to know there’s now a definitive, mathematically sanctioned solution to the bus-catcher’s bind.

New Scientist reports that Scott Kominers and some fellow Harvard mathematicians have come up with a formula for making the choice between waiting and walking - and you don’t even need a calculator.

Happiness life strategy

If neither option is clearly preferable (it doesn’t work if there’s a long wait between buses and a short walk to your destination or vice versa) then the formula says waiting, however vexatious*, is the preferred option.

Of course you can still choose to walk and get there later, but Kominers suggests you’ll save yourself frustration by making this decision pre-bus stop.

So put an end to vacillating and adopt Kominers’s solution. You’ll have a less stressful wait and a more relaxed ride - and you’ll probably be happier when you get where you’re going.

That is, unless you think you should take the train?

*My tip for making the wait less vexatious is to actually do The Bus Stop - simply copy the moves from the video. If nothing else, you’ll likely have the waiting area to yourself.

Image konr4d




Happiness Life Strategy: Know your personality

29 02 2008

imageNo matter what your personality make-up, you can make choices that bring you greater happiness. You just have to understand the pros and cons of your personality traits.

In Happiness Strategy 12: Make peace with your personality we learned the ‘Big-Five’ dimensions of personality are extraversion, agreeableness, conscientiousness, openness and neuroticism and we saw that extraversion and neuroticism are particularly related to happiness.

According to Daniel Nettle of Newcastle University in the UK, regardless of your personality composition there’s an ideal environment for you (New Scientist 9 February 2008).

Nettle notes that for each personality dimension there’s both an upside and downside.

  • In his own study extraverts had more sexual partners and enjoyed greater career and economic success (they’re also more likely to be ‘born happy’ as well as act in ways that promote happiness). On the other hand extraverts suffered more injury- and accident-related hospitalization and greater family instability, including divorce.
  • Agreeable people attract and keep friends and enjoy plenty of social support. The cost, however, is often their own priorities, which they sacrifice for the sake of others.
  • Conscientiousness can help a person gets things done but it can also close their eyes to opportunities that distractible people notice and exploit.
  • Openness can serve people well in historical/cultural contexts that value artistic qualities but not in times where more practical qualities are needed.
  • Neuroticism (which is related to unhappiness) can be an asset in times of genuine threat.

Nettle’s point is that knowing your personality puts you in touch with its pros and cons. And that helps you make better choices for happiness.

Happiness life strategy

It’s no secret to Happiness Strategies readers that I score high on both introversion and neuroticism. Realizing I had these predispositions gave me two of my most reliable and effective happiness strategies.

1. Recognizing my introverted tendencies led me to re-structure my life to have more alone time. I changed my work situation so I can work from home and I stopped going out so much. I now feel drained much less and enjoy my social time much more. I look forward to being with people!

2. Facing my inner neurotic helped me pay less attention to my worries - I realized they weren’t necessarily ‘real’. It also helped me accept and enjoy my pleasure in order and tidiness - it was simply a quirk, so I could enjoy it instead of trying to deconstruct or change it.

Want to know yourself a little better? You could do an online personality test or read more about the Big Five dimensions. But you probably already have a good sense of your personality, and can gain more insight simply by tuning in.

By becoming more aware of your predispositions you too can work with them for greater happiness. For instance:

  • Agreeableness
    If you feel resentful that your preferences often get pushed aside, realize your part in this. You could choose to raise your own priorities a smidge and lower your need to be loved by everyone all the time.
  • Conscientiousness
    If you’re not so good at being organized and getting things done, office manager may not be the career for you. Look for opportunities that reward flexibility and don’t require routine - perhaps sales or creative work.
  • Openness
    If you feel constrained by your friends you may benefit from looking for new people in your life. Instead of doing the things you find stifling, explore courses, classes or groups with interests that stimulate you. You might find a whole new dimension to yourself!

As Nettle says,

If your personality causes you grief, why not try changing the niche you occupy in this complex system that is modern life?

Technorati Tags: ,,,,,,,

Image konr4d




Happiness Life Strategy: Enjoy your stories, make friends & influence people

27 02 2008

image Relationships are important to happiness, so nurturing your social skills would seem a pretty wise happiness strategy. Now, is that something you can get from a book?

Well, yes and no - it depends on the book.

It may surprise you that research shows people panache is more polished in readers of Pride and Prejudice or Harry Potter than readers of How to Win Friends and Influence People.

According to a 2005 University of Toronto  study, reading fiction is linked to social skills like empathy and awareness. But non-fiction? Not so much.

The study was correlational, not causal, so we can’t say for sure that our reading matter makes us more or less socially adept.

I can see how reading fiction could boost people skills. After all, reading a novel gets you right into a character’s head - you experience ‘first hand’ another person’s feelings and cogitations, tuning you in to the depth of their internal life. It makes sense that your social insight would be cultivated. 

On the other hand, it could go in the other direction, with socially skilled people simply choosing to read more fiction. That would still be interesting. Perhaps reading fiction is a way to hone the skill, or perhaps it’s pleasurable to flex a strong empathy muscle.

Regardless of direction, there’s a link between reading stories and getting on with others. So it can’t hurt every now and then to put down your Q Is for Quantum Particle Physics and pick up A is for Alibi.

Technorati Tags: ,,,,

Image: iofoto




Not happy to say goodbye: Ali G on science & ‘techmology’

25 02 2008

I still haven’t gotten over the demise of Borat and Ali G, two characters who brought me great, chunky wads of happiness.

But I think it’s time to mark their passing with a little blog vigil. Two of my passions are science and technology, so this clip where ‘Ali G talks to some geezers about science and techmology (sic)’ seems a fitting farewell.

Even if you aren’t a fan, you’ll be hard pressed to find a better argument for evolution than the one so eloquently made here. And I challenge you not to laugh at the ‘geezers’ as they try to make sense of the yellow enigma that is Ali.

Enough intro. As Ali would say, ‘Can we see the muff please?’

Farewell, yellow-rapper-suited one. Respek.